#Immune repertoire capture standfod software#

#Immune repertoire capture standfod software#

The technology helps discover and develop antibody-based therapeutics, vaccines, diagnostics, and research reagents.Ītreca has recently licensed exclusive rights to the technology for all fields of use from Stanford University.Ītreca chief business officer and co-founder Paulette Dillon said, 'The structure of the agreement facilitates reaching the common goal of improving global health while at the same time allows each party to achieve its individual objectives. Significance The immune system defends against pathogens through a diverse population of T cells that display different antigen recognition surface receptor proteins. We present a flexible computational method and software tool, IGoR (Inference and Generation of Repertoires), that processes raw immune sequence reads from any source (cDNA or gDNA) and learns. Immune Repertoire Capture technology helps identify functional antibodies produced in patients during an immune response that have both utility themselves and can also be employed to identify the targets of an immune response. The parties to the agreement in the first four years have decided to focus their attention on malaria, HIV/AIDS, and tuberculosis.Ītreca chief executive officer, chief scientific officer and co-founder Tito Serafini said, 'This commitment from the foundation provides Atreca an opportunity to apply the Company’s Immune Repertoire CaptureTM technology to meet key challenges in global health.' These methods were used in pioneering studies of the TCR repertoire in a wide range of contexts, including in immune-mediated diseases, infections and cancer, leading, for example, to the. Researchers also refer to the TCR repertoire and BCR repertoire when studying T cells and B cells, respectively. Under the terms of the agreement, Atreca will apply the technology to particular infectious diseases and share the results with the foundation for use in the discovery and development of vaccines, therapeutics and diagnostics to be deployed in a defined group of countries. Using RNA-Seq, ImReP is able to capture on average 53.3 of the IGH repertoire, estimated as the sum of detected BCR-seq-confirmed clonotypes MiXCR is able to capture 40.1 (Fig. Immune repertoire refers to all of the unique T-cell receptor (TCR) and B-cell receptor (BCR) genetic rearrangements within the adaptive immune system.